PubMed - Active Sulforaphane - by Wellbeing200, a Social Impact Company

🧠 Studies on Dementia, Cognition & Cognitive Development

Targeting TLR4-Depended NLRP3 Inflammasome: Sulforaphane's Mechanism in Suppressing Neuroinflammation and Seizures in Epileptic Mice

This study aimed to elucidate the role of the TLR4 pathway in the antiepileptic effects of sulforaphane (SFN). C57BL/6 mice were randomized into control, SFN, epilepsy (EP), and SFN intervention group

2026.06.07 1 min read

🧬 Studies on Cancer Prevention & Anticancer Mechanisms

Anticancer Effects of Broccoli Sprout Extract and Sulforaphane Through ROS-Induced MAPK Pathway in Breast Cancer Cells and Xenografts

Breast cancer treatment remains challenging due to therapeutic resistance and the limited availability of effective molecular targets. We investigated the anticancer effects of sulforaphane (SFN) and

2026.05.29 1 min read

🧬 Studies on Cancer Prevention & Anticancer Mechanisms

Targeting Glyoxalase-1 Pathway with Natural Compounds: A Translational Strategy to Reduce Dicarbonyl Stress and Prevent Chronic Diseases

Methylglyoxal (MG) is a reactive dicarbonyl compound generated mainly as a byproduct of glycolysis. Excess accumulation of MG can promote protein glycation and the formation of advanced glycation end-

2026.05.29 1 min read

🧬 Studies on Cancer Prevention & Anticancer Mechanisms

Sulforaphane Synergies with Phytochemicals and Pharmaceuticals: Implications for Healthspan

Sulforaphane, a bioactive isothiocyanate found abundantly in cruciferous vegetables, has attracted significant attention for its chemopreventive and therapeutic potential, particularly in cancer. Ther

2026.05.29 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Efficacy and safety of Nrf2 activators for schizophrenia: a systematic review and meta-analysis

This systematic review and meta-analysis aimed to investigate the efficacy and safety of adding nuclear factor erythroid 2-related factor 2 (Nrf2) activators to antipsychotic treatments for individual

2026.05.24 1 min read

🧬 Studies on Cancer Prevention & Anticancer Mechanisms

Sulforaphane-Activated Functional Nucleic Acids for Cancer Therapy: Mechanisms, Delivery Strategies, and Nanomedicine Advances

Cancer therapy is increasingly shaped by the need for agents that are both mechanistically precise and clinically tolerable. Sulforaphane (SFN), a dietary isothiocyanate enriched in cabbage-family veg

2026.05.15 1 min read

🧬 Studies on Cancer Prevention & Anticancer Mechanisms

Molecular targeting of the meningioma cell signaling circuit reveals drug vulnerabilities including synergy between sulforaphane and focal adhesion kinase inhibition

CONCLUSIONS: Overall, we present a molecular targeting strategy for meningiomas that could pave the way for less invasive clinical management of these tumours and, as a result, help reduce patient mor

2026.04.20 1 min read

🧬 Studies on Cancer Prevention & Anticancer Mechanisms

Sulforaphane Synergizes With PD-1 Blockade Through Activating CD8(+) T Cells in Non-Small Cell Lung Cancer: Preclinical and Clinical Investigations

Anti-PD-1/PD-L1 therapy has achieved promising success across several tumor types; however, its efficacy is still far from satisfactory in non-small cell lung cancer (NSCLC). Combining therapies have

2026.04.06 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Neuroprotective Mechanisms of Erucin: Therapeutic Pathways in Neurodegenerative Disorders

Neurodegenerative Disorders (NDDs), including Alzheimer's Disease (AD), Parkinson's Disease (PD), Huntington's Disease (HD), Amyotrophic Lateral Sclerosis (ALS), Multiple Sclerosis (MS), and other les

2026.04.05 1 min read

🧬 Studies on Cancer Prevention & Anticancer Mechanisms

Sulforaphane Pre-Treatment Improves Alveolar Macrophage Killing After Alcohol-Induced Phagocytic Dysfunction In Vitro and in Galleria mellonella Larvae

Background: Alcohol is associated with increased mortality and morbidity globally. Pulmonary infections with opportunistic pathogens can occur in healthy humans; however, binge alcohol intoxication (≥

2026.03.30 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Neuroprotective Role of Nrf2 Activation Against ER Stress-Mediated Apoptosis in Obstructive Sleep Apnea

Obstructive sleep apnea (OSA) induces childhood cognitive impairment via chronic intermittent hypoxia (CIH), a process to which endoplasmic reticulum stress (ERS)-mediated apoptosis critically contrib

2026.03.29 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Therapeutic potential of sulforaphane in neurodegenerative diseases: mechanistic Insights into Nrf2, NF-kappaB, TrkB, SIRT1, MAPK, and JAK/STAT signalling pathways

No abstract

2026.03.29 1 min read

🧬 Studies on Cancer Prevention & Anticancer Mechanisms

Nanoformulated Phytochemicals Against Pancreatic Cancer: Emerging Advances in Therapeutic Strategies

CONCLUSION: Phytochemical-containing nanoformulations hold considerable promise as innovative therapeutic alternatives for PC. However, many available studies present notable limitations, such as the

2026.03.27 1 min read

🧬 Studies on Cancer Prevention & Anticancer Mechanisms

Therapeutic potential of isothiocyanates by targeting the NRF2 pathway

Isothiocyanates have been the focus of scientific research for over fifty years. Interest in these phytochemicals intensified following the discovery of sulforaphane, an isothiocyanate found in brocco

2026.03.17 1 min read

🧬 Studies on Cancer Prevention & Anticancer Mechanisms

The Chemopreventive and Anticancer Potential of Glucosinolates and Their Hydrolysis Products from Cruciferous Vegetables

CONCLUSIONS: The described compounds are bioavailable in humans and modulate the clinically relevant pathways linked to carcinogenesis. Larger, standardized interventions are needed to determine effec

2026.03.16 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Sulforaphane improved cognitive behavior in APP/PS1 mice via promoting structural and functional synaptic plasticity in the hippocampus

Cognitive dysfunction is the main clinical feature of Alzheimer's disease (AD), and oxidative stress is considered a critical contributor to AD pathogenesis. Sulforaphane (SFN), an aliphatic isothiocy

2026.03.15 1 min read

🧬 Studies on Cancer Prevention & Anticancer Mechanisms

Protective Effects of Curcumin and Sulforaphane Against Ionising Radiation-Induced Oxidative Stress and Inflammatory Responses in Rat Lung Tissue

Ionising radiation-induced lung injury is a major complication of thoracic radiotherapy, primarily driven by oxidative stress and inflammation. The current study evaluates and compares the protective

2026.03.02 1 min read

🧬 Studies on Cancer Prevention & Anticancer Mechanisms

Sulforaphane in Cancer Prevention and Therapy: A State-of-the-Art Review of Epidemiological Evidence, Molecular Mechanisms, and Translational Challenges

Sulforaphane (SFN), an aliphatic isothiocyanate derived from cruciferous vegetables such as broccoli, has emerged as a chemopreventive dietary agent. SFN exerts multifaceted anticancer effects through

2026.03.02 1 min read

🧬 Studies on Cancer Prevention & Anticancer Mechanisms

Aflatoxin and Liver Cancer in China: The Evolving Research Landscape

Aflatoxins, particularly aflatoxin B(1) (AFB(1)), are among the most potent naturally occurring carcinogens and remain a major food-borne hazard in parts of Asia and Africa. China has generated a uniq

2026.02.28 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Efficacy of 42-month oral administration of glucoraphanin in preventing cognitive decline in individuals at elevated risk of dementia, including those with mild cognitive impairment: a randomized, double-blind, placebo-controlled pilot study

CONCLUSION: Long-term GLR supplementation may help preserve cognitive function in individuals at elevated risk for AD, particularly those with MCI. Larger trials are warranted to confirm efficacy and

2026.02.15 1 min read

🧬 Studies on Cancer Prevention & Anticancer Mechanisms

Efficacy and mechanisms of cisplatin and sulforaphane nanoparticles in alleviating cisplatin resistance in non-small cell lung cancer

CONCLUSIONS: The nSDDPs which were successfully synthesized in this study improved DDP resistance by activating the ferroptosis pathway and also exerted anti-tumor effects. Our findings provide new in

2026.02.11 2 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Sulforaphane-Mediated Multitarget Therapeutic Effects in Methylmercury-Induced ALS-Like Pathology: Comparative Analysis and Multifaceted Approach to Neuroprotection and Systemic Recovery

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder marked by motor neuron loss driven by oxidative stress, neuroinflammation, and dysregulated survival signaling. The obje

2026.02.08 1 min read

🧬 Studies on Cancer Prevention & Anticancer Mechanisms

Sulforaphane as a Multi-Scale Mechano-Modulator in Cancer: An Integrative Perspective

Cancer progression is driven not only by biochemical signals but also by abnormal physical forces within a stiffened tumor microenvironment. This review re-examines the anticancer compound sulforaphan

2026.01.30 1 min read

🧬 Studies on Cancer Prevention & Anticancer Mechanisms

Targeting Cancer Stem Cells with Phytochemicals: Molecular Mechanisms and Therapeutic Potential

Cancer stem cells (CSCs) represent a small but highly resilient tumor subpopulation responsible for sustained growth, metastasis, therapeutic resistance, and recurrence. Their survival is supported by

2026.01.30 1 min read

🧬 Studies on Cancer Prevention & Anticancer Mechanisms

Elucidation of Sulforaphane-Mediated Effects on the Cellular Human Metabolome Using Metabolic Profiling

Sulforaphane (SFN) is an isothiocyanate derived from glucoraphanin, which occurs in broccoli. Several human health-promoting effects are attributed to the consumption of cruciferous vegetables or food

2026.01.20 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

NRF2 AT THE CROSSROADS OF PARKINSON'S DISEASE AND AGING: MECHANISTIC INSIGHTS AND TRANSLATIONAL PERSPECTIVES

Parkinson's disease (PD) is a multifactorial neurodegenerative disorder characterized by dopaminergic neuronal loss, α-SYNUCLEIN aggregation, mitochondrial dysfunction, oxidative stress, and neuroinfl

2026.01.18 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Sulforaphane reduces reactive astrocyte-mediated neuron apoptosis in vitro by inhibiting the MAPK/NF-kappaB signaling pathway in Abeta42 oligomer-activated astrocytes

CONCLUSIONS: SFN attenuates astrocyte-mediated neuron apoptosis by inhibiting the MAPK/NF-κB signaling pathway in Aβ42 oligomer-activated astrocytes.

2026.01.18 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Treatment trials for negative symptoms in schizophrenia

PURPOSE OF REVIEW: Negative symptoms in schizophrenia remain an unmet treatment need. Recent guidelines and meta-analyses suggest that some pharmacological and psychosocial interventions show modest e

2026.01.18 1 min read

🧬 Studies on Cancer Prevention & Anticancer Mechanisms

Inhibiting autophagy enhances anti-cancer properties of sulforaphane

Bladder cancer (BC) has an extremely low survival rate due to its tendency to metastasize. The antimalarial drug chloroquine (CQ) can inhibit BC progression and invasiveness by targeting basal autopha

2026.01.17 1 min read

🧬 Studies on Cancer Prevention & Anticancer Mechanisms

Biologically Informed Machine Learning Prioritizes Dietary Supplements That Protect Neural Crest Cells from Ethanol-Induced Epigenetic Dysregulation and Developmental Impairment

The impairment of neural crest cells (NCCs) plays a pivotal role in the pathogenesis of fetal alcohol spectrum disorders (FASD). Epigenetic regulators mediate ethanol-induced disruptions in NCC develo

2026.01.12 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Nutritional strategies against dementia in rural populations

Dementia is a progressive neurodegenerative disorder that represents a growing challenge to global health, especially in aging populations. The burden of dementia is high in rural communities, where a

2026.01.04 1 min read

🧬 Studies on Cancer Prevention & Anticancer Mechanisms

Effects of the Pharmacological Modulation of NRF2 in Cancer Progression

Nuclear factor erythroid 2-related factor 2 (NRF2) orchestrates redox balance, metabolism, and cellular stress responses, acting as both a tumor suppressor and promoter depending on the disease stage.

2026.01.02 1 min read

🧬 Studies on Cancer Prevention & Anticancer Mechanisms

Major Plant-Based Compounds for the Prevention and Treatment of Melanoma-A Mini Review

Melanoma, particularly the malignant type owing to its aggressive metastatic potential, is one of the most severe cancers. When detected early, the cure rate of melanoma is very promising and has a hi

2026.01.01 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Developing Topics

BACKGROUND: AD is a neurodegenerative disease that is characterized by inflammation and oxidative stress. A transcription factor called nuclear factor erythroid 2-related factor 2 (NRF2) controls anti

2025.12.28 1 min read

🧬 Studies on Cancer Prevention & Anticancer Mechanisms

Effects of azithromycin on lung oxidative injury and immune function in mice infected with <em>Mycoplasma pneumoniae</em> based on the Nrf2/ARE signaling pathway

CONCLUSIONS: Azithromycin ameliorates MP infection-induced lung injury and oxidative stress and strengthens immune function in mice, which may be achieved by activating the Nrf2/ARE signaling pathway.

2025.12.26 1 min read

🧬 Studies on Cancer Prevention & Anticancer Mechanisms

Sulforaphane-cysteine elicits apoptosis through JNK-mediated caspase activation in oral squamous cell carcinoma cells

Sulforaphane-cysteine (SFN-Cys) is a naturally-occurring form of plant-derived isothiocyanate metabolites that displays several tumor-suppressive properties. However, the oncostatic potential of SFN-C

2025.12.26 1 min read

🧬 Studies on Cancer Prevention & Anticancer Mechanisms

Plant-Derived Antioxidants as Modulators of Redox Signaling and Epigenetic Reprogramming in Cancer

Redox imbalance and epigenetic dysregulation, which both contribute to tumor initiation, survival, and resistance to therapy, are intimately linked to the progression of cancer. Reactive oxygen specie

2025.12.26 1 min read

🧬 Studies on Cancer Prevention & Anticancer Mechanisms

Ginkgetin reverses cisplatin resistance in cervical cancer by regulating the Nrf2/HO-1 signaling pathway to induce ferroptosis

This study investigates whether Ginkgetin(GK) reverses cisplatin(DDP) resistance in cervical cancer cells by modulating the Nrf2/HO-1 signaling axis to induce ferroptosis, and preliminarily elucidates

2025.12.19 1 min read

🧬 Studies on Cancer Prevention & Anticancer Mechanisms

Enzymatically Synthesized Poly(Gallic Acid) Modulates Methionine Synthase Activity and Neuroblastoma Morphology in Contrast to Phthalate-Type Endocrine Disruptors

The effect of the enzyme-mediated poly(gallic acid) (PGAL) as a potential redox regulator or redox activity compound (RAC) on the morphology of human neuroblastoma SH-SY5Y cells and its methionine syn

2025.12.15 1 min read

🧬 Studies on Cancer Prevention & Anticancer Mechanisms

Nanoliposome-mediated delivery of sulforaphane suppresses Ehrlich ascites carcinoma growth and improves liver integrity and therapeutic outcomes in a murine model

The anticancer activity of sulforaphane (SFN) involves multiple signaling pathways, but its mechanism against Ehrlich Ascites Carcinoma (EAC) in mice remains unclear. This study evaluated the antitumo

2025.12.02 1 min read

🧬 Studies on Cancer Prevention & Anticancer Mechanisms

New fluorescently labeled isothiocyanate derivatives as a potential cancer theranostic tool

Cancer is the plague of the 20^(th) and 21^(st) centuries, affecting sick individuals, their families, and entire micro- and macro-communities. Despite the efforts of scientists to search for new diag

2025.11.27 2 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Efficacy of Antioxidant-Based Pharmacological Therapies in Autism Spectrum Disorder: A Systematic Review

CONCLUSION: Antioxidant-based pharmacological therapy evidenced contrasting responses to a variety of core symptoms in ASD. Despite significant evidence of improvement in some ASD symptom scales, ther

2025.11.19 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Promoting cognitive health through the nexus of gut microbiota and dietary phytochemicals

The intricate interactions between gut microbiota and cognitive function have become a forefront topic at the convergence of neuroscience and nutrition. This review systematically evaluates the bidire

2025.11.19 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Role of inflammatory response in benzo[a]pyrene-induced noradrenergic axon degeneration in mouse brain

Environmental pollution is a major contributor to neurotoxicity and could explain various nervous system dysfunctions. The polycyclic aromatic hydrocarbon (PAH) benzo[a]pyrene (B[a]P) is widely presen

2025.11.18 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Sulforaphane as a potential therapeutic agent: a comprehensive analysis of clinical trials and mechanistic insights

Sulforaphane (SFN), a bioactive compound derived from glucoraphanin in cruciferous vegetables such as broccoli, has been extensively studied for its therapeutic potential across diverse disease catego

2025.11.18 1 min read

🧬 Studies on Cancer Prevention & Anticancer Mechanisms

Nutritional, Therapeutic, and Functional Food Perspectives of Kale (Brassica oleracea var. acephala): An Integrative Review

Kale (Brassica oleracea var. acephala) is a non-heading leafy vegetable of the Brassicaceae family, widely recognized for its dense nutritional profile and diverse phytochemical composition. This revi

2025.11.18 1 min read

🧬 Studies on Cancer Prevention & Anticancer Mechanisms

Sulforaphane: a natural organosulfur having potential to modulate apoptosis and survival signalling in cancer

Owing to its ever-growing range of pharmacological advantages, sulforaphane, an isothiocyanate from cruciferous vegetables such as broccoli, is becoming increasingly popular. This review aims to provi

2025.11.18 1 min read

🧬 Studies on Cancer Prevention & Anticancer Mechanisms

Novel magnolol-sulforaphane hybrids as potent antitumor agents: synthesis and biological characterization

The natural product-based hybrid strategy is a promising approach for innovative drug discovery. Leveraging the privileged architecture of sulforaphane-a prominent anticancer natural product-we engine

2025.11.18 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Efficacy and safety of sulforaphane in schizophrenia: a systematic review and meta-analysis of randomized controlled trials

CONCLUSION: The study provides initial insights into sulforaphane's potential therapeutic effects in schizophrenia, showing modest improvements in general psychopathology and negative symptoms, with f

2025.11.18 1 min read

🧬 Studies on Cancer Prevention & Anticancer Mechanisms

Sulforaphane in cancer precision medicine: from biosynthetic origins to multiscale mechanisms and clinical translation

Sulforaphane (SFN), an isothiocyanate derived from glucoraphanin in cruciferous vegetables, has evolved from a dietary antioxidant to a sophisticated multi-target agent in oncology. While its roles in

2025.11.18 1 min read