🧠 Studies on Dementia, Cognition & Cognitive Development

Multitarget therapeutic potential of sulforaphane in ethidium bromide-induced neurotoxicity in multiple sclerosis-like pathology: comparison with omaveloxolone and dimethyl fumarate on neuroprotection and systemic recovery

Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by demyelination, neuroinflammation, and neurodegeneration. This study investigates the neuroprotective potential of Sulforaphane

2026.07.12 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

beta-sitosterol and next-generation neuroprotection for multi-target strategies and the gut-brain axis in neurodegenerative diseases

Neurodegenerative disorders such as Alzheimer's and Parkinson's diseases arise from complex interactions among oxidative stress, neuroinflammation, metabolic dysfunction, and dysregulated signaling ne

2026.07.12 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Medicinal Plants and Their Bioactive Phytochemicals as Emerging Therapeutic Strategies for Alzheimer's Disease: An Integrative Review of Preclinical and Clinical Evidence

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by β-amyloid deposition, tau hyperphosphorylation, mitochondrial dysfunction, oxidative stress, neuroinflammation, an

2026.07.05 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Plant-derived bioactives, the gut-brain axis, and neurodegenerative diseases: mechanistic roles of diet-microbiota interactions

Diet is increasingly recognized as a potential upstream modulator of the gut-brain axis (GBA) through its effects on the microbiome, microbial metabolites, and host immune and endocrine responses. The

2026.06.21 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Downregulation of Nrf2 and upregulation of TXNIP/NLRP3 signaling Induce postoperative cognitive dysfunction via oxidative stress and pyroptosis in the hippocampus

Postoperative Cognitive Dysfunction (POCD) is a neurocognitive complication after anaesthesia and surgery, with oxidative stress as a key pathological driver. Nuclear factor erythroid-related factor 2

2026.06.14 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Targeting TLR4-Depended NLRP3 Inflammasome: Sulforaphane's Mechanism in Suppressing Neuroinflammation and Seizures in Epileptic Mice

This study aimed to elucidate the role of the TLR4 pathway in the antiepileptic effects of sulforaphane (SFN). C57BL/6 mice were randomized into control, SFN, epilepsy (EP), and SFN intervention group

2026.06.07 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Efficacy and safety of Nrf2 activators for schizophrenia: a systematic review and meta-analysis

This systematic review and meta-analysis aimed to investigate the efficacy and safety of adding nuclear factor erythroid 2-related factor 2 (Nrf2) activators to antipsychotic treatments for individual

2026.05.24 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Neuroprotective Mechanisms of Erucin: Therapeutic Pathways in Neurodegenerative Disorders

Neurodegenerative Disorders (NDDs), including Alzheimer's Disease (AD), Parkinson's Disease (PD), Huntington's Disease (HD), Amyotrophic Lateral Sclerosis (ALS), Multiple Sclerosis (MS), and other les

2026.04.05 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Neuroprotective Role of Nrf2 Activation Against ER Stress-Mediated Apoptosis in Obstructive Sleep Apnea

Obstructive sleep apnea (OSA) induces childhood cognitive impairment via chronic intermittent hypoxia (CIH), a process to which endoplasmic reticulum stress (ERS)-mediated apoptosis critically contrib

2026.03.29 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Therapeutic potential of sulforaphane in neurodegenerative diseases: mechanistic Insights into Nrf2, NF-kappaB, TrkB, SIRT1, MAPK, and JAK/STAT signalling pathways

No abstract

2026.03.29 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Sulforaphane improved cognitive behavior in APP/PS1 mice via promoting structural and functional synaptic plasticity in the hippocampus

Cognitive dysfunction is the main clinical feature of Alzheimer's disease (AD), and oxidative stress is considered a critical contributor to AD pathogenesis. Sulforaphane (SFN), an aliphatic isothiocy

2026.03.15 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Efficacy of 42-month oral administration of glucoraphanin in preventing cognitive decline in individuals at elevated risk of dementia, including those with mild cognitive impairment: a randomized, double-blind, placebo-controlled pilot study

CONCLUSION: Long-term GLR supplementation may help preserve cognitive function in individuals at elevated risk for AD, particularly those with MCI. Larger trials are warranted to confirm efficacy and

2026.02.15 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Sulforaphane-Mediated Multitarget Therapeutic Effects in Methylmercury-Induced ALS-Like Pathology: Comparative Analysis and Multifaceted Approach to Neuroprotection and Systemic Recovery

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder marked by motor neuron loss driven by oxidative stress, neuroinflammation, and dysregulated survival signaling. The obje

2026.02.08 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

NRF2 AT THE CROSSROADS OF PARKINSON'S DISEASE AND AGING: MECHANISTIC INSIGHTS AND TRANSLATIONAL PERSPECTIVES

Parkinson's disease (PD) is a multifactorial neurodegenerative disorder characterized by dopaminergic neuronal loss, α-SYNUCLEIN aggregation, mitochondrial dysfunction, oxidative stress, and neuroinfl

2026.01.18 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Sulforaphane reduces reactive astrocyte-mediated neuron apoptosis in vitro by inhibiting the MAPK/NF-kappaB signaling pathway in Abeta42 oligomer-activated astrocytes

CONCLUSIONS: SFN attenuates astrocyte-mediated neuron apoptosis by inhibiting the MAPK/NF-κB signaling pathway in Aβ42 oligomer-activated astrocytes.

2026.01.18 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Treatment trials for negative symptoms in schizophrenia

PURPOSE OF REVIEW: Negative symptoms in schizophrenia remain an unmet treatment need. Recent guidelines and meta-analyses suggest that some pharmacological and psychosocial interventions show modest e

2026.01.18 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Nutritional strategies against dementia in rural populations

Dementia is a progressive neurodegenerative disorder that represents a growing challenge to global health, especially in aging populations. The burden of dementia is high in rural communities, where a

2026.01.04 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Developing Topics

BACKGROUND: AD is a neurodegenerative disease that is characterized by inflammation and oxidative stress. A transcription factor called nuclear factor erythroid 2-related factor 2 (NRF2) controls anti

2025.12.28 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Efficacy of Antioxidant-Based Pharmacological Therapies in Autism Spectrum Disorder: A Systematic Review

CONCLUSION: Antioxidant-based pharmacological therapy evidenced contrasting responses to a variety of core symptoms in ASD. Despite significant evidence of improvement in some ASD symptom scales, ther

2025.11.19 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Promoting cognitive health through the nexus of gut microbiota and dietary phytochemicals

The intricate interactions between gut microbiota and cognitive function have become a forefront topic at the convergence of neuroscience and nutrition. This review systematically evaluates the bidire

2025.11.19 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Role of inflammatory response in benzo[a]pyrene-induced noradrenergic axon degeneration in mouse brain

Environmental pollution is a major contributor to neurotoxicity and could explain various nervous system dysfunctions. The polycyclic aromatic hydrocarbon (PAH) benzo[a]pyrene (B[a]P) is widely presen

2025.11.18 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Sulforaphane as a potential therapeutic agent: a comprehensive analysis of clinical trials and mechanistic insights

Sulforaphane (SFN), a bioactive compound derived from glucoraphanin in cruciferous vegetables such as broccoli, has been extensively studied for its therapeutic potential across diverse disease catego

2025.11.18 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Efficacy and safety of sulforaphane in schizophrenia: a systematic review and meta-analysis of randomized controlled trials

CONCLUSION: The study provides initial insights into sulforaphane's potential therapeutic effects in schizophrenia, showing modest improvements in general psychopathology and negative symptoms, with f

2025.11.18 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

The study titled “Neuroprotective Effects of Sulforaphane in a Rat Model of Alzheimer’s Disease Induced by Aβ (1–42) Peptides,”

published in Neurochemistry International in October 2024, reports that sulforaphane exhibits significant protective effects against Alzheimer’s-type dementia (AD).

2025.04.18 1 min read