🧠 Studies on Dementia, Cognition & Cognitive Development

✅Sulforaphane protects brain cells through antioxidant and anti-inflammatory effects, helping slow cognitive decline. It may improve memory, learning, and neurodevelopmental disorders such as autism by activating NRF2, reducing neuroinflammation, and preventing amyloid buildup. 🔖Keywords: cognitive health, Alzheimer’s prevention, autism, neuroprotection, NRF2, brain inflammation

Efficacy of 42-month oral administration of glucoraphanin in preventing cognitive decline in individuals at elevated risk of dementia, including those with mild cognitive impairment: a randomized, double-blind, placebo-controlled pilot study

CONCLUSION: Long-term GLR supplementation may help preserve cognitive function in individuals at elevated risk for AD, particularly those with MCI. Larger trials are warranted to confirm efficacy and

2026.02.15 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Sulforaphane-Mediated Multitarget Therapeutic Effects in Methylmercury-Induced ALS-Like Pathology: Comparative Analysis and Multifaceted Approach to Neuroprotection and Systemic Recovery

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder marked by motor neuron loss driven by oxidative stress, neuroinflammation, and dysregulated survival signaling. The obje

2026.02.08 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

NRF2 AT THE CROSSROADS OF PARKINSON'S DISEASE AND AGING: MECHANISTIC INSIGHTS AND TRANSLATIONAL PERSPECTIVES

Parkinson's disease (PD) is a multifactorial neurodegenerative disorder characterized by dopaminergic neuronal loss, α-SYNUCLEIN aggregation, mitochondrial dysfunction, oxidative stress, and neuroinfl

2026.01.18 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Sulforaphane reduces reactive astrocyte-mediated neuron apoptosis in vitro by inhibiting the MAPK/NF-kappaB signaling pathway in Abeta42 oligomer-activated astrocytes

CONCLUSIONS: SFN attenuates astrocyte-mediated neuron apoptosis by inhibiting the MAPK/NF-κB signaling pathway in Aβ42 oligomer-activated astrocytes.

2026.01.18 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Treatment trials for negative symptoms in schizophrenia

PURPOSE OF REVIEW: Negative symptoms in schizophrenia remain an unmet treatment need. Recent guidelines and meta-analyses suggest that some pharmacological and psychosocial interventions show modest e

2026.01.18 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Nutritional strategies against dementia in rural populations

Dementia is a progressive neurodegenerative disorder that represents a growing challenge to global health, especially in aging populations. The burden of dementia is high in rural communities, where a

2026.01.04 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Developing Topics

BACKGROUND: AD is a neurodegenerative disease that is characterized by inflammation and oxidative stress. A transcription factor called nuclear factor erythroid 2-related factor 2 (NRF2) controls anti

2025.12.28 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Efficacy of Antioxidant-Based Pharmacological Therapies in Autism Spectrum Disorder: A Systematic Review

CONCLUSION: Antioxidant-based pharmacological therapy evidenced contrasting responses to a variety of core symptoms in ASD. Despite significant evidence of improvement in some ASD symptom scales, ther

2025.11.19 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Promoting cognitive health through the nexus of gut microbiota and dietary phytochemicals

The intricate interactions between gut microbiota and cognitive function have become a forefront topic at the convergence of neuroscience and nutrition. This review systematically evaluates the bidire

2025.11.19 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Role of inflammatory response in benzo[a]pyrene-induced noradrenergic axon degeneration in mouse brain

Environmental pollution is a major contributor to neurotoxicity and could explain various nervous system dysfunctions. The polycyclic aromatic hydrocarbon (PAH) benzo[a]pyrene (B[a]P) is widely presen

2025.11.18 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Sulforaphane as a potential therapeutic agent: a comprehensive analysis of clinical trials and mechanistic insights

Sulforaphane (SFN), a bioactive compound derived from glucoraphanin in cruciferous vegetables such as broccoli, has been extensively studied for its therapeutic potential across diverse disease catego

2025.11.18 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

Efficacy and safety of sulforaphane in schizophrenia: a systematic review and meta-analysis of randomized controlled trials

CONCLUSION: The study provides initial insights into sulforaphane's potential therapeutic effects in schizophrenia, showing modest improvements in general psychopathology and negative symptoms, with f

2025.11.18 1 min read

🧠 Studies on Dementia, Cognition & Cognitive Development

The study titled “Neuroprotective Effects of Sulforaphane in a Rat Model of Alzheimer’s Disease Induced by Aβ (1–42) Peptides,”

published in Neurochemistry International in October 2024, reports that sulforaphane exhibits significant protective effects against Alzheimer’s-type dementia (AD).

2025.04.18 1 min read

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🎉 Manmeoksul Launch

2025.10.01 1 min read