📄 Paper Information
Title: Neuroprotective Effects of Sulforaphane in a Rat Model of Alzheimer’s Disease Induced by Aβ (1–42) Peptides
Authors: Wasi Uzzaman Khan et al.
Journal: Neurochemistry International, October 2024
🔬 Study Overview
Model: Alzheimer’s disease induced by intracerebral injection of Aβ(1–42) peptides
Treatment: Oral administration of sulforaphane for 28 days
Objective: To verify the effects of sulforaphane on cognitive recovery and neuronal protection
🧠 Key Experimental Results
| Parameter | Aβ-Induced Group | Sulforaphane-Treated Group |
|---|---|---|
| Working Memory (Y-maze) | Decreased | Restored |
| Oxidative Stress (MDA) | Increased | Decreased |
| Nrf2 Expression | Reduced | Increased |
| BDNF Levels | Decreased | Elevated |
| Tissue Damage | Neurodegeneration | Improved |
📌 Conclusion Summary
Sulforaphane activates the brain’s antioxidant defense (Nrf2 pathway) and increases neurotrophic factors such as BDNF, leading to improved cognitive performance and reduced neuronal damage in Alzheimer’s disease.
These findings suggest sulforaphane as a promising natural compound for neuroprotection and cognitive preservation.