- Paper Title: Effect of Broccoli Sprout Extract and Baseline Gut Microbiota on Fasting Blood Glucose in Prediabetes: A Randomized, Placebo-Controlled Trial
- Published: February 10, 2025
๐งช Study Overview
- Participants: 89 adults diagnosed with prediabetes (aged 35โ75, BMI 27โ45)
- Design: 12-week randomized, double-blind, placebo-controlled trial
- Intervention: Broccoli sprout extract (BSE) providing 150 ฮผmol/day of sulforaphane vs. placebo
๐ Results
- The BSE group showed a mean fasting glucose reduction of 0.2 mmol/L (p = 0.04).
- In a specific subgroup (mild obesity, low insulin resistance, and low insulin secretion capacity), the reduction reached up to 0.4 mmol/L.
- A bacterial gene, BT2160, in Bacteroides species played a role in sulforaphane activation, enhancing its blood glucoseโlowering effect.
๐ฌ Interaction with Gut Microbiota
The study revealed that the efficacy of sulforaphane depends on individual gut microbiota composition.
The presence of specific bacteria harboring genes involved in sulforaphane activation was strongly correlated with higher plasma sulforaphane levels and greater glycemic improvement.
๐ Conclusion & Implications
This research suggests that sulforaphane may support blood glucose regulation in prediabetic individuals, with its effects varying according to personal metabolic profiles and gut microbiota composition.
Thus, personalized dietary approaches incorporating sulforaphane could be a promising strategy for prediabetes management and metabolic health optimization.
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